Development trend of the hottest medical plastic p

2022-10-18
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Development trends of medical plastic packaging film (I)

promising application prospects

medical plastic packaging film is widely used, not only for the packaging of tablets, powders, granular drugs, but also for the lining of paste, liquid and drug carton packaging, as well as the packaging of medical devices. Common films include shrink film, winding film, multilayer composite film, etc. In pharmaceutical packaging, the glass bottles and plastic bottles used in the past are gradually replaced by plastic films, especially the plastic flexible packaging of medical liquids, such as infusion bags and plasma bags, is developing more rapidly

according to the survey conducted by American industrial market research company Freedonia grouplnc., the annual average growth rate of global pharmaceutical packaging demand from 1997 to 2007 reached 4.3% (see Table 1). According to the research on the European pharmaceutical packaging market released by the British market intelligence organization, the total annual sales of the European packaging market is $3.246 billion, and the traditional Chinese medicine packaging films and bags account for 28%

the annual output value of China's pharmaceutical packaging industry is about 15billion yuan, with an average annual growth rate of more than 10%. In recent years, the application proportion of plastic products in medical packaging in China is rapidly increasing. Statistics show that the proportion of aluminum and plastic packaging for pharmaceutical tablets in China has increased from 10% in 1990 to 40% at present. Medical plastic film has become a new development hotspot of film. It is estimated that the demand for plastic packaging for pharmaceutical tablets and capsules in China will increase to 4billion in 2005

there are many kinds of medical plastic films, and the widely used ones mainly include PE, PP, pet, pen (polyethylene naphthalate) Pa, PVA, PVC, PVDC, PC and the newly developed cyclic olefin copolymer (COC), among which polyolefin is the largest

diversified development of raw materials

1. Pe

according to the Research Report of mastio on the market situation of PE film, PE medical plastic packaging film is one of the fastest growing varieties of plastic film. It is predicted that the global demand for PE medical plastic film will increase at an average annual rate of 7% in the next few years. P there is still a particularly large demand space for the foam granulator industry. E the largest potential growth market for medical films is anti infection medical supplies packaging bags, followed by disposable lining films, small packaging bags and films for medical device packaging. At present, more than 40 companies around the world produce medical PE packaging products. The top five companies are clopay Corp, P1ant, maxxin medical products, Rexam medical packaging and Banta health care, with a market share of about 50%

among PE medical films, LLDPE has the fastest growth in consumption. In 2003, the consumption of LLDPE medical films accounted for 52% of the total consumption of PE medical films in the market, and it is expected to reach 54% in 2006. The main reason for the rapid development of LLDPE medical film is that it can produce films with higher strength than LDPE under the same thickness, so as to produce thin films, save raw materials and reduce costs

in recent years, the annual output of LDPE medical film has exceeded 40000 tons, accounting for 39% of the total consumption, ranking second. The consumption of HDPE and MDPE is small, and the market share is less than 10%

2, pp

the blend of metallocene catalyzed vinyl plastic and PP can improve the embrittlement resistance of PP film after radiation, and can be used in the packaging of medical devices

in recent years, through the modification of PP, it has made great progress in the development of pharmaceutical liquid packaging bags. After screening the raw materials, buxter believes that if PP is used to make flexible packaging bags for medicinal liquids, it needs to integrate the high melting point of isotactic PP and the elastic block structure of flexible pp. these two materials have excellent softness and flexibility, good low-temperature toughness and melting point higher than 121oc. At the same time, because their density is about 30% lower than PVC, the unit cost is close to PVC. It is reported that Mont tensile machine 1 must remove the initial force before clamping the extension meter. The flexible polyolefin fpos of ellcataloy copolymer company and Huntsman company have met the above requirements. At present, rxloy products have been produced in the United States and Asia, and the production license has been obtained in Europe. However, the crystallinity of fpos is 17%~25% lower than that of PP 99%, and it has a certain viscosity, which is difficult to deal with. Therefore, it is usually necessary to improve its performance through blending. For example, adflexks353 with a density of 0.89g/cm3 must be used as the surface layer to ensure its strength and melting point above 121oc. The surface layer needs to use a special resin with high transparency level to provide the required transparency. In addition, the shortcomings of high haze on the surface of PP can be overcome by coextrusion process. The heat sealing performance of PP can be improved by formula design. The thickness can be reduced and the cost can be reduced by using PP resin with a density of 0.89g/cm3

Amoco and Stanford University jointly developed PP elastomer with PVC like properties. MLLDPE developed by Exxon and Dow Chemical Company is also being used in medical liquid flexible packaging bags. They have excellent cleanliness, transparency and mechanical properties, and also have the potential cost advantage of thinning the film thickness. However, mLLDPE has a low melting point and cannot be used to disinfect at 121oc for 20 minutes. Therefore, it is mainly used as a collection bag for human excretion. If it is used as an infusion bag and blood transfusion bag, it needs further modification

in the development process of polyolefin as a substitute material for PVC, because medical products require the use of special polyolefin resin in the processes of disinfection, sterilization, filling, sealing, use and so on, the high cost has become one of the important reasons why polyolefin cannot quickly replace PVC. However, by changing the processing conditions and using new additives, the performance of PP is gradually improving in recent years. In addition, problems related to the assembly line, such as heat sealing and disinfection conditions, can be solved by Sandvik materials technology: through equipment improvement. Therefore, it is just around the corner that PP film can be used in the fourth generation infusion bags and plasma bags

3. PVC

PVC has good chemical resistance, mechanical properties and electrical properties, but poor light resistance and thermal stability. PVC film can be produced by calendering or extrusion blow molding. Because PVC is a heat sensitive resin with high hardness, heat stabilizers and plasticizers must be added during the processing of soft films. Its soft and semi-rigid films can be widely used in medical infusion bags and blood transfusion bags. When used in medical packaging materials, the content of vinyl chloride monomer in PVC resin should be less than LMG/kg, and non-toxic heat stabilizers and non-toxic and non migratory plasticizers should be used to ensure the safety of products. Rigid PVC film can be used as the film for drug packaging, mostly transparent or amber film, which is filled with tablets after vacuum blistering forming small pits, and then compounded with the cover material coated with EVA heat sealing agent. In order to improve the heat sealing with the cover material, the PVC inner layer is also coated with EVA or PVDC coating

in recent years, because the phthalate plasticizers used in PVC flexible packaging are considered toxic and the environmental problems caused by PVC flexible packaging bags are not easy to recycle after use, they have encountered serious threats and challenges in use, especially in some European countries, the PVC pharmaceutical packaging market is gradually shrinking

4, pa

pa film has strong toughness and good puncture resistance, durability and chemical resistance. Its use temperature range is wide, but its hygroscopicity is large, and its heat sealing performance is poor. Therefore, it is mostly used with polyolefins and other composite films. Due to the good comprehensive performance of PA film, it is very suitable for protecting medical devices that have been disinfected during storage and transportation, so medical device packaging will be a new application field of PA film

5. CTEF film

ctfe film is made of ethylene/chlorotrifluoroethylene copolymer, which has high transparency, flame retardancy and permeability; Excellent. The film has a unique application range. It is still soft below - 195.50c, and its melting point is 182~204oc

6. Pet

biaxially stretched PET film has very high mechanical strength and rigidity, high heat resistance, good drug resistance, excellent transparency and gloss, small water and oxygen permeability, and good taste retention and non-toxic. PET film can be directly used in contact with drugs, and is often used in the packaging of tablets, especially traditional Chinese medicine tablets. In addition, because of its high flavor retention and heat resistance, it can be used as a barrier layer in multilayer composite films to ensure that the tablets do not deteriorate within the period of validity

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